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May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. However, that information will still be included in details such as numbers of replies. florence nightingale concept 2 via de boleto According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. 16.6k members in the AlternativeHealth community. weight loss, anorexia). " For a better experience, please enable JavaScript in your browser before proceeding. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. I have no further scientific evidence. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. You must log in or register to reply here. The Remarkable Heart-Friendy Properties of Avocados. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. by D.ap Tue Feb 21, 2017 10:40 am, Powered by phpBB Forum Software phpBB Limited. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to 'replacement' therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. Could be another marmalade how would we know? [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. I cried with joy when I found out there was something really wrong with me. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. radioactive treatments. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes I very much appreciate the information you shared. Metab.87 (2): 48999. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. Privacy Policy. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. Why not simply call it selenium deficiency? Scan this QR code to download the app now. Once I got on the medication, the symptoms disappeared. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Due to excessive bot signups along with nefarious actors we are limiting forum registration. PMID 11836274. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. Researchers are currently studying. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Not what people like me are saying. In an attempt to show causation, the article notes "patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Baked or Fried avocado fries [Vegetarian]. I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. I wonder if only t3 treatments are preferable than t4 and t3 ? The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. Ultimately, this Italian study brings further attention to one of a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. A place for patients and relatives. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. I do not believe in random events, of nature or otherwise. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. It looks at correlations, as if they had any merit on their own. PMID: 23539727, [16] Alan R Gaby. Maybe because they "treat" only with T4 and not T3? Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Find how some diseases can be healed with alternative medicine, and share your experience with The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. My Endocrinologist was, and continues to be, open about the elevated risk for thyroid cancer due to the multiple. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. Correlation is NOT causation. I wish I could say that my story was atypical. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. I hope that with increased knowledge we will all find the right road. It was the therapist that I went to that referred me to a specialist who ran the correct tests. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Monaldi Arch Chest Dis 2003, 59:140145. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. I have so much to say about this I could write a book. (February 2002). Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? That's all. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. There are several books out there written about the topic. For more information, please see our [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. Another recently approved drug is tepotinib (Tepmetko). The Dangers of Tylenol: Is it Time to for the FDA Chile: Psychiatrist Leads Crusade To Legalize Mari 13 Things Sure To Slow Down Your Metabolism. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.